Research Focus

Our Laboratory research is focused on molecular pathways and therapeutic approaches of Alzheimer’s Disease, Frontotemporal Dementia (FTD) and related dementias. We have expanded beyond our knowledge on tauopathy and study the molecular mechanisms involved in TDP-43 proteinopathy in the multi-etiology of AD, LATE and FTD disease spectrum. Our laboratory has developed a comprehensive research program to study the impact of TDP-43 and tau proteins in neuropathology, neuroinflammation, blood brain barrier permeability and cellular stress. Specifically, we study mechanistic pathways (hypusinated Eif5a) and post-translation modifications (acetylation, citrullination) that regulate TDP-43 pathology in cellular and animal models.

Our Methodology


We utilize imaging techniques for immunohistochemical analysis of tissue paired with cellular confocol microscopy 

Animal Models

Our laboratory utilizes transgenic animal models of tauopathy and TDP-43 proteinopathy for basic and therapeutic research

Cellular Mechanisms

We utilize several cellular models to investigate hypusine eIF5A mechanism  and stress granule in proteinopathy 

Lab Milestones

Funding Sources

  • NIH/NIA/NINDS Program Project: 5P01AG078116-02
  • NIH/NIMGMS COBRE: P20GM148326-01
  • NIH/NIA ADRC Development Grant: P30AG072946-03
  • NIH/ NIA R01s: 1R01AG084670-01
  • DOD-ALSRP Therapeutic Idea Award/ Gismo Therapeutic: W81XWH2210379

Interested in joining our team?