424 Sanders-Brown
(859) 218-3859
Maj-Linda.Selenica@uky.edu

SELENICA LAB

Sanders-Brown Center on Aging, University of Kentucky

A LITTLE ABOUT THE PI

Maj-Linda Selenica, PhD

Dr. Selenica performed her graduate studies in Sweden where she studied the role of amyloid beta and tau proteins in Alzheimer Disease. Directly after her PHD, she received a postdoctoral fellowship at the laboratory of Drs. Dave Morgan and Marcia Gordon, University of South Florida, where she studied therapeutic approaches in tauopathy utilizing mouse models of AD/FTD.

Dr. Selenica joined College of Pharmacy at University of South Florida (2013) as a founding faculty member and basic scientist. As an independent PI, Dr. Selenica focuses in the pathological mechanisms behind TDP-43 and tauopathy in neurodegenerative disorders. In 2019 Selenica lab relocated to the University of Kentucky, Sanders-Brown Center (SBCoA), where they joined the Alzheimer’s disease Center (UK-ADC) and a collaborative group of neuroscientist and neurologist experts focused on Aging and dementia.

Research Focus

Our Laboratory research is focused on molecular pathways and therapeutic approaches of Alzheimer’s Disease, Frontotemporal Dementia (FTD) and related dementias. We have expanded beyond our knowledge on tauopathy and study the molecular mechanisms involved in TDP-43 proteinopathy in the multi-etiology of AD, LATE and FTD disease spectrum. Our laboratory has developed a comprehensive research program to study the impact of TDP-43 and tau proteins in neuropathology, neuroinflammation, blood brain barrier permeability and cellular stress. Specifically, we study mechanistic pathways (hypusinated Eif5a) and post-translation modifications (acetylation, citrullination) that regulate TDP-43 pathology in cellular and animal models.

Alzheimer Disease (AD)

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Limbic-predominant age-related TDP-43 encephalopathy (LATE)

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Inflammation

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Lab Milestones

Total funding to date, CoI + PI

Number of publications

Primary and Corresponding

Our Methodology

The laboratory uttilizes cutting edge technology and novel assays to measure TDP-43 protein aggregation and accumulation

Imaging 

We utilize imaging techniques for immunohistochemical analysis of tissue paired with cellular confocol microscopy 

Animal Models

Our laboratory utilizes transgenic animal models of tauopathy and TDP-43 proteinopathy for basic and therapeutic research

Cellular Mechanisms

We utilize several cellular models to investigate hypusine eIF5A mechanism  and stress granule in proteinopathy 

Interested in joining our team?

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