Our Laboratory research is focused on molecular pathways and therapeutic approaches of Alzheimer’s Disease, Frontotemporal Dementia (FTD) and related dementias. We have expanded beyond our knowledge on tauopathy and study the molecular mechanisms involved in TDP-43 proteinopathy in the multi-etiology of AD, LATE and FTD disease spectrum. Our laboratory has developed a comprehensive research program to study the impact of TDP-43 and tau proteins in neuropathology, neuroinflammation, blood brain barrier permeability and cellular stress. Specifically, we study mechanistic pathways (hypusinated Eif5a) and post-translation modifications (acetylation, citrullination) that regulate TDP-43 pathology in cellular and animal models.
The laboratory uttilizes cutting edge technology and novel assays to measure TDP-43 protein aggregation and accumulation