789 South Limestone Street
(859) 218-3859
Maj-Linda.Selenica@uky.edu

Publications

2021

Loon A*, Zamudio F*, Sanneh A, Brown B, Smeltzer S, BrownLow ML, Quadri, Z, Peters M, Weeber E, Nash K, Lee DC, Gordon MN, Morgan D, Selenica MLB. Accumulation of C-terminal cleaved tau is distinctly associated with cognitive deficits, synaptic plasticity impairment, and neurodegeneration in aged mice. 2021 Aug 19. doi: 10.1007/s11357-021-00408-z. PMID:3441058.

Sandusky-Beltran LA, Kovalenko A, Placides DS, Ratnasamy K, Ma C, Hunt JB Jr, Liang H, Calahatian JIT, Michalski C, Fahnestock M, Blair LJ, Darling AL, Baker JD, Fontaine SN, Dickey CA, Gamsby JJ, Nash KR, Abner E, Selenica MB, Lee DC. Polyamine dysregulation precipitates anxiety, cognitive impairment, and tau neuropathology. J Clin Invest. 2021 Feb 15;131(4):e126299. doi: 10.1172/JCI126299.

Ma C, Hunt JB, Selenica MB, Sanneh A, Sandusky-Beltran LA, Watler M, Daas R, Kovalenko A, Liang H, Placides D, Cao C, Lin X, Orr MB, Zhang B, Gensel JC, Feola DJ, Gordon MN, Morgan D, Bickford PC, Lee DC. Arginase 1 Insufficiency Precipitates Amyloid- β Deposition and Hastens Behavioral Impairment in a Mouse Model of Amyloidosis. Front Immunol. 2021 Jan 14;11:582998. doi: 10.3389/fimmu.2020.582998. eCollection 2020.PMID: 33519806. 

2020

Quadri Z, Johnson N, Zamudio F, Housley BS, Liu J, Hunt J, Brown B, Peters M, Smeltzer S, Weeber E, Nash N, Lee DC, Selenica MLB. Overexpression of human wtTDP-43 causes impaired hippocampal plasticity and behavior deficits in CAMKII-tTa transgenic mouse model.  Mol Cell Neurosci 2020. DOI: 10.1016/j.mcn.2019.103418, PMID: 31705957.

Amando-Joly A, Zamudio F, Kesarwani A, Quadri Z, Rangel-Rocha P, Lee DC, Nash K, Morgan D, Gordon MN, Selenica MLB. CCL2 overexpression in the brain promotes glial activation and accelerates tau pathology in a mouse model of tauopathy. Front Immunol. 2020 May 20;11:997. doi: 10.3389/fimmu.2020.00997. eCollection 2020.PMID: 32508844.

Smeltzer S, Quadri Z, Zamudio F, Hunter J, Orso-Cruz C, Lee DC, Loon A, Stewart N, Miller A, Saji, S, Selenica MLB. Hypusination of eIF5A induces TDP-43 mislocalization and accumulation into stress granules. Biochim Biophys Acta Mol Basis Dis. 2020 Aug 31:165939. doi: 10.1016/j.bbadis.2020.165939. PMID: 32882370.

Zamudio F, Loon A, Smeltzer S, Lee DC, Laneras C, Saji, S, Selenica MLB. TDP-43 mediated blood-brain-barrier dysfunction promotes neurodegeneration in a low-grade systemic inflammation mouse mode. J Neuroinflammation. 2020 Sep 26;17(1):283. doi: 10.1186/s12974-020-01952-9.PMID: 32979923. 

Liu T, Jung-A A Woo, Bukhari MZ, Lepochat P, Chacko A, Selenica MLB, Yan Y, Kotsiviras P, Buosi SC, Zhao X, Kang D. CHCHD10-regulted Opa1-mitofililn complex mediates TDP-43 induced mitochondrial phenotypes associated with Frontotemporal dementia. FASEB J, PMID: 32369233, DOI: 10.1096/fj.201903133RR.

2019

Sandusky-Beltran, L. A., Kovalenko, A., Hunt, J. B., Darling, A. L., Baker, J. D., Martin, M. D., Fontaine, S. N., Dickey, C. A., Lussier, A. L., Weeber, E. J., Selenica, M.-L. B., Nash, K. R., Gordon, M. N., Morgan, D., Lee, D. C.. Spermidine/ spermine-N1-acetyltransferase (SSAT) disruption prevents a tau-induced polyamine stress response and impacts hippocampal tau neuropathology. Alzheimer’s Res Ther. 2019; 11: 58.   doi: 10.1186/s13195-019-0507-y. PMID: 31253191.

2016

Selenica MLB, Reid P, Pena G, Alvarez J, Hunt JB Jr, Nash KR, Morgan D, Gordon MN, Lee DC. Adeno associated viral-mediated intraosseous labeling of bone marrow derived cells for CNS tracking (2016).J Immunol Methods. S0022-1759(16)30008-4. doi: 10.1016/j.jim. PMID: 26784524. PubMed PMID: 26784524; PubMed Central PMCID: PMC4852145.

Andreasson KI, Bachstetter AD, Colonna M, Ginhoux F, Holmes C, Lamb B, Landreth G, Lee DC, Low D, Lynch MA, Monsonego A, O'Banion MK, Pekny M, Puschmann T, Russek-Blum N, Sandusky LA, Selenica MLB, Takata K, Teeling J, Town T, Van Eldik LJ. Targeting innate immunity for neurodegenerative disorders of the central nervous system. J Neurochem.2016 Jun 1. doi: 10.1111/jnc.13667. PMID: 27248001. Review. PubMed PMID: 272480.

Grewal R, Haghighi M, Huang S, Loon A, Smith A, Lin X, Teten N, Hill A, Selenica MLB. Investigating the disparity of dementia related plasma biomarkers among ethnic mild AD female patients. Alzheimer’s Res Ther. 2016 Oct 18;8(1):43. doi: 10.1186/s13195-016-0211-0  PMID: 27756387. 

2005 - 2015

Lindberg C, Selenica MLB, Westlind-Danielsson A, Schultzberg M (2005) beta-amyloid protein structure determines the nature of cytokine release from rat microglia. Journal of Molecular Neuroscience 27:1-12.

Selenica ML, Wang X, Ostergaard-Pedersen L, Westlind-Danielsson A, Grubb A (2007) Cystatin C reduces the in vitro formation of soluble A beta 1-42 oligomers and protofibrils. Scandinavian Journal of Clinical & Laboratory Investigation 67:179-190.

Selenica ML, Jensen HS, Larsen AK, Pedersen ML, Helboe L, Leist M, Lotharius J (2007) Efficacy of small-molecule glycogen synthase kinase-3 inhibitors in the postnatal rat model of tau hyperphosphorylation. British Journal of Pharmacology 152:959-979.

Kaeser SA, Herzig MC, Coomaraswamy J, Kilger E, Selenica ML, Winkler DT, Staufenbiel M, Levy E, Grubb A, Jucker M (2007) Cystatin C modulates cerebral beta-amyloidosis. Nature Genetics 39:1437-1439.

Lee DC, Rizer J, Selenica MLB, Reid P, Kraft C, Johnson A, Blair L, Gordon MN, Dickey CA, Morgan D (2010) LPS- induced inflammation exacerbates phosphotau pathology in rTg4510 mice. Journal of Neuroinflammation 16;7:56. PubMed Central PMCID: PMC2949628.

Tatum W, Worley AV, Selenica MLB (2011). Disobidience and Driving in Patients with Epilepsy. Epilepsy Behavior 10.1016.

Li Q, Nash K, Shah B, Lebson L, Grimm J, Rosenthal A, Selenica MLB, Morgan D, Gordon MN. Chronological Age Impacts Immunotherapy and Monocyte Uptake Independent of Amyloid Load. Journal of Neuroimmune Pharmacology, 10.1007/s11481-011-9329-9, 2012. PubMed PMID: 22198698.

Selenica MLB, Brownlow M, Jimenez PJ, Lee DC, Pena G, Dickey CA, Gordon MN, Morgan D. Ab-42 Oligomers aggrevate tau pathology in rTg4510 mouse model. Neurodegenerative Disease, 2013;11(4):165-81. doi: 10.1159/000337230. PubMed Central PMCID: PMC3739054. 

Lee DC, Rizer J, Hunt J, Selenica MLB, Gordon MN, Morgan D. Review: Experimental manipulations of microglia in mouse models of Alzheimer’s pathology. Activation reduces amyloid but hastens tau pathology. Neuropathology and Applied Neurobiology 2012. PubMed Central PMCID: PMC4300851. 

Nash K, Lee DC, Hunt J, Morganti J, Selenica MLB, Moran P, Reid P, Brownlow M, Yang C, Gemma C, Bickford P, Gordon MN, Morgan D. Fractalkine Overexpression Suppresses Tau Pathology In A Mouse Model Of Tauopathy. Neurobiology Aging. 2013 Jun;34(6):1540-8.doi:10.1016. PubMed PMID: 23332170. 

Lee DC, C Ruiz, Selenica MLB, Lebson L, Rizer J, Mercer M, Gordon MN, Morgan D. Aging induces classical microglia activation but mitigates alternative activation responses in the mouse CNS.  Neurobiol Aging. 2013 Jun;34(6):1610-20.doi:10.1016. PubMed Central PMCID: PMC3652232. 

Carty N, Nash K, Brownlow, Cruit D, Wilcock D, Selenica MLB, Lee DC, Gordon MN, Morgan D. Intracranial injections of AAV expressing NEP but not IDE reduces amyloid pathology in APP+PS1 transgenic mice. PLoS ONE 2013 8(3); E59626.DOI:10.1371. PubMed Central PMCID: PMC3610740.

Selenica MLB, Alvarez J, Lee DC, Nash. K, Reid P, Chao C, Morgan D, Gordon MN. CCL2 overexpression in CNS induces microglia polarization. Journal of Neuroinflammation. 2013, 10:86, DOI: 10.1186/10.1186/1742-2094-10-86.PubMed Central PMCID: PMC3726363.

Selenica MLB, Benner L, Housley SB,  Manchec B, Lee DC, Kalin J, Bergman JA, Kozikowski A, Gordon MN, Morgan D. HDAC6 Inhibition Improves Memory and Reduces Total Tau levels in a Mouse Model of Tau Deposition. Alzheimer’s Res Ther. 2014 Feb 27;6(1):12.

Selenica MLB*, Davtyan H, Housley BS, Blair L, Zhang B, Nordhuse BA, Liu J, Lee DC, Gordon MN,  Morgan D, Dickey CH. Active immunization with wild type and P301L tau results in an immune response and changes in levels of tau in rTg4510 mouse model. J Neuroinflammation. 2014 Sep 3;11:152. doi: 10.1186/s12974-014-0152-0. PMID: 25183004. PubMed Central PMCID: PMC4167523. *Corresponding author

Brownlow ML, Joly-Amado A, Azam S, Elza M, Selenica MLB, Pappas C, Small B, Engelman R, Gordon MN, Morgan D. Partial rescue of memory deficits induced by calorie restriction in a mouse model of tau deposition. Behav Brain Res. 2014 Sep 1;271:79-88. doi: 10.1016/j.bbr.2014.06.001. PMID: 24925454.

Hunt JB, Nash N, Placides D, Moran P, Rodrigez-Opsina S, Savlia M, Reid P, Yang CG, Selenica MLB, Gordon MN, Morgan D, Lee DC*. Sustained Arginase-1 Expression Modulates Pathological Tau Deposits in a Mouse Model of Tauopathy. J. Neurosci 2015 Nov 4; 35 (44) 14842-60. doi: 10.1523/JNEUROSCI.3959-14.2015. PMID: 26538654.Neurosci. 2015 Nov 4;35(44):14842-60. PubMed PMID: 26538654. 

Blair LJ, Frauen HD, Zhang B, Nordhues BA, Bijan S, Lin YC, Zamudio F, Hernandez LD, Sabbagh JJ, Selenica MLB, Dickey C. Tau depletion prevents progressive blood-brain barrier damage in a mouse model of tauopathy. ANEC-D-15-00002R1, doi:10.1186/s40478-015-0186-2PMID: 26784524. Acta Neuropathologica Communications.

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